Cardiorespiratory Fitness and C-Reactive Protein Among a Tri-Ethnic Sample of Women

DOI Web Site 被引用文献5件
  • Michael J. LaMonte
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • J. Larry Durstine
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • Frank G. Yanowitz
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • Tobin Lim
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • Katrina D. DuBose
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • Paul Davis
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.
  • Barbara E. Ainsworth
    From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC.

抄録

<jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Background</jats:italic> </jats:bold> — </jats:italic> </jats:bold> Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness (“fitness”) is related with lower CHD risk; however, its relationship with CRP is relatively unknown. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Methods and Results</jats:italic> </jats:bold> — </jats:italic> </jats:bold> Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55±11 year; 28±6 kg/m <jats:sup>2</jats:sup> ). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness ( <jats:italic>P</jats:italic> =0.002), increased across tertiles of BMI ( <jats:italic>P</jats:italic> =0.0007), and varied by race ( <jats:italic>P</jats:italic> =0.002). After adjustment for covariates, lower CRP ( <jats:italic>P</jats:italic> <0.05) was observed across tertiles of fitness among NA and CA, but not AA. Among all women, after adjusting for race and covariates, the odds of high-risk CRP (>0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Conclusions</jats:italic> </jats:bold> — </jats:italic> </jats:bold> The health benefits from enhanced fitness may have an antiinflammatory mechanism. </jats:p>

収録刊行物

  • Circulation

    Circulation 106 (4), 403-406, 2002-07-23

    Ovid Technologies (Wolters Kluwer Health)

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