Family History and Cardiovascular Risk in Familial Hypercholesterolemia

DOI Web Site 被引用文献2件
  • Albert Wiegman
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • Jessica Rodenburg
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • Saskia de Jongh
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • Joep C. Defesche
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • Henk D. Bakker
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • John J.P. Kastelein
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).
  • Eric J.G. Sijbrands
    From the Departments of Pediatrics and Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (A.W., J.R., S.d.J., J.C.D., H.D.B., J.J.P.K); and the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (E.J.G.S.).

書誌事項

タイトル別名
  • Data in More Than 1000 Children

抄録

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Elevated LDL cholesterol (LDL-C) levels in childhood predict cardiovascular disease (CVD) later in life. Familial hypercholesterolemia (FH) represents the paradigm of this relation. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> The objectives of this study were to (1) establish the LDL-C level that provides the most accurate diagnosis of FH in children from families with known FH and (2) assess whether lipoprotein variation in these children is associated with premature CVD in relatives. Foremost, however, it was our objective to identify children with FH who are at high risk and in need of early intervention. A total of 1034 consecutive children from FH kindreds were investigated. First, LDL-C levels >3.50 mmol/L had a 0.98 post-test probability (95% CI, 0.96 to 0.99) of predicting the presence of an LDL receptor mutation. Second, children with FH in the highest LDL-C tertile (>6.23 mmol/L) had a 1.7-times higher incidence (95% CI, 1.24 to 2.36) of having a parent with FH suffering from premature CVD ( <jats:italic>P</jats:italic> =0.001). In addition, such a parent was found 1.8 times more often (95% CI, 1.20 to 2.59) among children with FH who had HDL-C <1.00 mmol/L ( <jats:italic>P</jats:italic> =0.004). Last, children with FH whose lipoprotein(a) was >300 mg/L had a 1.45-times higher incidence (95% CI, 0.99 to 2.13) of having a parent with FH suffering from premature CVD ( <jats:italic>P</jats:italic> =0.05). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> In FH families, LDL-C levels allow accurate diagnosis of FH in childhood. Moreover, increased LDL-C and lipoprotein(a) and decreased HDL-C levels in children identify FH kindreds with the highest CVD risk. </jats:p>

収録刊行物

  • Circulation

    Circulation 107 (11), 1473-1478, 2003-03-25

    Ovid Technologies (Wolters Kluwer Health)

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