Analysis of 1-Year Clinical Outcomes in the SIRIUS Trial

• David R. Holmes

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Martin B. Leon

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Jeffrey W. Moses

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Jeffrey J. Popma

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Donald Cutlip

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Peter J. Fitzgerald

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Charles Brown

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Tim Fischell

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Shing Chiu Wong

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Mark Midei

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• David Snead

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

• Richard E. Kuntz

  From Saint Mary’s Hospital (D.R.H.), Rochester, Minn; Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); Brigham and Women’s Hospital (J.J.P., R.E.K., D.C.), Boston, Mass; Stanford University Medical Center (P.J.F.), Stanford, Calif; Piedmont Hospital (C.B.), Atlanta, Ga; Borgess Medical Center (T.F.), Kalamazoo, Mich; Cornell University New York Presbyterian Hospital (S.C.W.), New York, NY; Saint Joseph’s Hospital (M.M.), Baltimore, Md; and Cordis (D.S.), Warren, NJ.

書誌事項

タイトル別名

• A Randomized Trial of a Sirolimus-Eluting Stent Versus a Standard Stent in Patients at High Risk for Coronary Restenosis

抄録

Background— This study evaluated a large group of patients enrolled in a double-blind randomized trial of the sirolimus-eluting stent to document whether the initial clinical improvement seen in previous smaller series is maintained out to 12 months and to study the potential treatment effect in patient subsets known to be at increased risk of restenosis. Methods and Results— A total of 1058 patients with de novo native coronary stenosis undergoing clinically indicated percutaneous coronary intervention were randomly assigned to sirolimus-eluting stent (533) or control bare stent (525). Procedural success and in-hospital outcomes were excellent and did not differ between the 2 groups. At 9 months, clinical restenosis, defined as target-lesion revascularization, was 4.1% in the sirolimus limb versus 16.6% in the control limb ( P <0.001). At 12 months, the absolute difference in target-lesion revascularization continued to increase and was 4.9% versus 20% ( P <0.001). There were no differences in death or myocardial infarction rates. In high-risk patient subsets, defined by vessel size, lesion length, and presence of diabetes mellitus, there was a 70% to 80% reduction in clinical restenosis at 1 year. Conclusions— Placement of the sirolimus-eluting stent results in continued clinical improvement at 1 year after initial implantation, with significant reduction in clinical restenosis as defined by target-lesion revascularization. Between 9 and 12 months, the absolute reduction of clinical restenosis continues to increase. Even in high-risk subsets of patients, there is a 70% to 80% relative reduction in clinical restenosis at 12 months with this drug-eluting stent.

収録刊行物

• Circulation

  Circulation 109 (5), 634-640, 2004-02-10

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1360855570030037760
• NII論文ID: 30022669849
• DOI: 10.1161/01.cir.0000112572.57794.22
• ISSN: 15244539
• ISSN: 00097322
• ISSN: http://id.crossref.org/issn/00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000112572.57794.22
• データソース種別:
  • Crossref
  • CiNii Articles