One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent

• Gregg W. Stone

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Stephen G. Ellis

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• David A. Cox

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• James Hermiller

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Charles O’Shaughnessy

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• James Tift Mann

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Mark Turco

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Ronald Caputo

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Patrick Bergin

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Joel Greenberg

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Jeffrey J. Popma

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

• Mary E. Russell

  From The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (G.W.S.); Cleveland Clinic Foundation (S.G.E.); Mid Carolina Cardiology, Charlotte, NC (D.A.C.); St. Vincent’s Hospital, Indianapolis, Ind (J.H.); Elyria Memorial Hospital, Elyria, Ohio (C.O.); WakeMed, Raleigh, NC (J.T.M.); Washington Adventist Hospital, Tacoma Park, MD (M.T.); St. Joseph’s Hospital, Syracuse, NY (R.C.); Sacred Heart Medical Center, Eugene, Ore (P.B.); Florida Hospital, Orlando,...

書誌事項

タイトル別名

• The TAXUS-IV Trial

抄録

Background— The safety and efficacy of the slow-release, polymer-based, paclitaxel-eluting stent after implantation in a broad cross section of de novo coronary lesions at 1 year are unknown. Methods and Results— In the TAXUS-IV trial, 1314 patients with single de novo coronary lesions 10 to 28 mm in length, with reference-vessel diameter 2.5 to 3.75 mm, coverable by a single study stent, were prospectively randomized to the slow-release, polymer-based, paclitaxel-eluting TAXUS stent or an identical-appearing bare-metal EXPRESS stent. By actuarial analysis, the TAXUS stent compared with the bare-metal stent reduced the 12-month rates of target-lesion revascularization by 73% (4.4% versus 15.1%, P <0.0001), target-vessel revascularization by 62% (7.1% versus 17.1%, P <0.0001), target-vessel failure by 52% (10.0% versus 19.4%, P <0.0001), and composite major adverse cardiac events by 49% (10.8% versus 20.0%, P <0.0001). The 1-year rates of cardiac death (1.4% versus 1.3%), myocardial infarction (3.5% versus 4.7%), and subacute thrombosis (0.6% versus 0.8%) were similar between the paclitaxel-eluting and control stents, respectively. Between 9 and 12 months, there were significantly fewer myocardial infarctions (0% versus 1.1%, P =0.007), target-vessel revascularizations (2.4% versus 5.8%, P =0.002), and major adverse cardiac events (2.4% versus 6.3%, P =0.0009) in the paclitaxel-eluting stent than in the control stent group, respectively. Conclusions— The relative efficacy reported at 9 months for the polymer-based, paclitaxel-eluting TAXUS stent compared with the EXPRESS stent is preserved and continues to increase at 1 year, with no safety concerns apparent.

収録刊行物

• Circulation

  Circulation 109 (16), 1942-1947, 2004-04-27

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1362262943750749568
• NII論文ID: 30022670210
• DOI: 10.1161/01.cir.0000127110.49192.72
• ISSN: 15244539
• ISSN: 00097322
• ISSN: http://id.crossref.org/issn/00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000127110.49192.72
• データソース種別:
  • Crossref
  • CiNii Articles