Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

• Frank C. Gibson

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Charlie Hong

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Hsin-Hua Chou

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Hiromichi Yumoto

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Jiqiu Chen

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Egil Lien

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Jodie Wong

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

• Caroline Attardo Genco

  From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

抄録

Background— Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. Methods and Results— To directly test the connection between periodontal disease and atherosclerosis, apoE −/− mice were orally challenged with the periodontal disease pathogen Porphyromonas gingivalis or an invasion-impaired P gingivalis fimbriae-deficient mutant (FimA−). Both wild-type P gingivalis and the FimA− mutant were detected in blood and aortic arch tissue of apoE −/− mice by PCR after challenge. ApoE −/− mice challenged with wild-type P gingivalis presented with increased atherosclerotic plaque and expressed the innate immune response markers Toll-like receptor (TLR)-2 and TLR-4 in aortic tissue. Despite detection of the FimA− mutant in the blood and in aortic arch tissue, apoE −/− mice challenged with the FimA− mutant did not present with periodontal disease, upregulation of TLRs, or accelerated atherosclerosis. Furthermore, we demonstrate that immunization to control P gingivalis -elicited periodontal disease concomitantly prevents P gingivalis -accelerated atherosclerosis. Conclusions— We conclude that invasive P gingivalis accelerates atherosclerosis.

収録刊行物

• Circulation

  Circulation 109 (22), 2801-2806, 2004-06-08

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1362825895621995520
• NII論文ID: 30022670286
• DOI: 10.1161/01.cir.0000129769.17895.f0
• ISSN: 15244539
• ISSN: 00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000129769.17895.F0
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