Early Morning Attenuation of Endothelial Function in Healthy Humans

• Maria E. Otto

  From the Mayo Foundation, Rochester, Minn.

• Anna Svatikova

  From the Mayo Foundation, Rochester, Minn.

• Rodrigo Bellio de Mattos Barretto

  From the Mayo Foundation, Rochester, Minn.

• Simone Santos

  From the Mayo Foundation, Rochester, Minn.

• Michal Hoffmann

  From the Mayo Foundation, Rochester, Minn.

• Bijoy Khandheria

  From the Mayo Foundation, Rochester, Minn.

• Virend Somers

  From the Mayo Foundation, Rochester, Minn.

抄録

Background— Cardiovascular events such as myocardial infarction, sudden death, and stroke have a peak incidence in the early hours after waking. The mechanisms involved in this circadian variation are not clear. Endothelial dysfunction is associated with increased risk for cardiovascular events. We tested the hypothesis that endothelial function is reduced in the early morning, around the time of waking, compared with measurements obtained both before sleep and later in the day in healthy humans. Methods and Results— We studied 30 subjects (19 men, 11 women; mean age, 41.6 years). All participants underwent polysomnography to exclude obstructive sleep apnea or other sleep disorders. Brachial artery flow–mediated endothelium-dependent vasodilation (FMD) and endothelium–independent dilation (non-FMD) were measured on 3 different occasions: before subjects went to sleep (9 pm ), the next morning immediately after waking (6 am ), and during the late morning 5 hours after waking (11 am ). All subjects had normal sleep with good sleep efficiency of 84±2%. Compared with before sleep, FMD decreased markedly in the early morning after waking and recovered by late morning (9 pm , 7.5±1%; 6 am , 4.4±0.7%; 11 am , 7.7±1%; P =0.02). Non-FMD was similar for the 3 periods of observation (9 pm , 17.3±1.6%; 6 am , 17.2±1.3%; 11 am , 18.5±1.7%). Conclusions— FMD is blunted in the early morning in healthy subjects. Decreased endothelial function in the early morning may have implications for our understanding of the morning peak in cardiac and vascular events.

収録刊行物

• Circulation

  Circulation 109 (21), 2507-2510, 2004-06

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1362825895229459712
• NII論文ID: 30022670310
• DOI: 10.1161/01.cir.0000128207.26863.c4
• ISSN: 15244539
• ISSN: 00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000128207.26863.C4
• データソース種別:
  • Crossref
  • CiNii Articles