Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese

DOI Web Site 被引用文献139件
  • Hiroyasu Iso
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Minatsu Kobayashi
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Junko Ishihara
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Satoshi Sasaki
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Katsutoshi Okada
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Yoshikuni Kita
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Yoshihiro Kokubo
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...
  • Shoichiro Tsugane
    From the Department of Public Health Medicine (H.I.), Major of Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki-ken, Japan; Epidemiology and Prevention Division (M.K., J.I., S.T.), Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; National Institute of Health and Nutrition (S.S.), Tokyo, Japan; Department of Public Health (K.O.), University of Ehime, Ehime, Japan; Department of Health Science ...

書誌事項

タイトル別名
  • The Japan Public Health Center-Based (JPHC) Study Cohort I

抄録

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Once- or twice-weekly consumption of fish (or a small amount of fish intake) reduces the risk of coronary heart disease and sudden cardiac death in Western countries. It is uncertain whether a high frequency or large amount of fish intake, as is the case in Japan, further reduces the risk. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> To examine an association between high intake of fish and n3 polyunsaturated fatty acids and the risk of coronary heart disease, a total of 41 578 Japanese men and women aged 40 to 59 years who were free of prior diagnosis of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed up from 1990–1992 to 2001. After 477 325 person-years of follow-up, 258 incident cases of coronary heart disease (198 definite and 23 probable myocardial infarctions and 37 sudden cardiac deaths) were documented, comprising 196 nonfatal and 62 fatal coronary events. The multivariable hazard ratios (HRs) and 95% confidence intervals in the highest (8 times per week, or median intake=180 g/d) versus lowest (once a week, or median intake=23 g/d) quintiles of fish intake were 0.63 (0.38 to 1.04) for total coronary heart disease, 0.44 (0.24 to 0.81) for definite myocardial infarction, and 1.14 (0.36 to 3.63) for sudden cardiac death. The reduced risk was primarily observed for nonfatal coronary events (HR=0.43 [0.23 to 0.81]) but not for fatal coronary events (HR=1.08 [0.42 to 2.76]). Strong inverse associations existed between dietary intake of n3 fatty acids and risk of definite myocardial infarction (HR=0.35 [0.18 to 0.66]) and nonfatal coronary events (HR=0.33 [0.17 to 0.63]). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Compared with a modest fish intake of once a week or &20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle-aged persons. </jats:p>

収録刊行物

  • Circulation

    Circulation 113 (2), 195-202, 2006-01-17

    Ovid Technologies (Wolters Kluwer Health)

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