-
- Susanne Feil
- From the Institut für Pharmakologie und Toxikologie, Technische Universität, München, Germany.
-
- Franz Hofmann
- From the Institut für Pharmakologie und Toxikologie, Technische Universität, München, Germany.
-
- Robert Feil
- From the Institut für Pharmakologie und Toxikologie, Technische Universität, München, Germany.
抄録
<jats:p>The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/lox-mediated cell fate mapping in mice to investigate the role of SM22α, an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholesterolemic ApoE-deficient mice, genetic ablation of SM22α resulted in increased atherosclerotic lesion area and a higher proportion of proliferating SMC-derived plaque cells. These results identify a role for SM22α in the regulation of SMC phenotype during atherogenesis.</jats:p>
収録刊行物
-
- Circulation Research
-
Circulation Research 94 (7), 863-865, 2004-04-16
Ovid Technologies (Wolters Kluwer Health)
- Tweet
詳細情報
-
- CRID
- 1363388844255248384
-
- NII論文ID
- 30022675788
-
- ISSN
- 15244571
- 00097330
-
- データソース種別
-
- Crossref
- CiNii Articles