Elevated C-Reactive Protein Augments Increased Arterial Stiffness in Subjects With the Metabolic Syndrome
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- Hirofumi Tomiyama
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Yutaka Koji
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Minoru Yambe
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Kohki Motobe
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Kazuki Shiina
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Zaydun Gulnisa
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Yoshio Yamamoto
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
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- Akira Yamashina
- From the Second Department of Internal Medicine, Tokyo Medical University (Y.Y.) Health Care Center, Kajima Corporation, Tokyo, Japan.
抄録
<jats:p> We examined whether the presence of an increasing number of metabolic syndrome “disorders” was associated with an increasing pulse wave velocity, which is recognized as a marker of cardiovascular risk, and evaluated whether an elevated plasma C-reactive protein level augments this increasing pulse wave velocity. Using a cross-sectional study design, C-reactive protein, metabolic syndrome–related anthropometric parameters, and pulse wave velocity were measured in 5752 middle-aged Japanese men (44±10 years old). In linear regression analyses, all of the metabolic “disorders” and the logarithm of the C-reactive protein significantly correlated with pulse wave velocity. Multiple linear regression analysis demonstrated that triglycerides, HDL cholesterol, mean blood pressure, fasting glucose, and the logarithm of the C-reactive protein were significant independent positive predictors of pulse wave velocity (R-square=0.38). The presence of an increasing number of metabolic “disorders” in the subjects was associated with an increasing pulse wave velocity (no disorders 1228±139 cm/s ≥3 disorders 1437±250 cm/s; <jats:italic>P</jats:italic> <0.01). Among subjects with the metabolic syndrome, pulse wave velocity was higher in cases with (1508±278 cm/s) than in those without an elevated C-reactive protein (1427±243 cm/s; <jats:italic>P</jats:italic> <0.01). In conclusion, an increase in arterial stiffness may constitute a pathophysiological basis for the increased risk of cardiovascular disease in patients with the metabolic syndrome and that an elevated C-reactive protein level may aggravate this cardiovascular risk. </jats:p>
収録刊行物
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- Hypertension
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Hypertension 45 (5), 997-1003, 2005-05
Ovid Technologies (Wolters Kluwer Health)
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詳細情報 詳細情報について
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- CRID
- 1360574094423198464
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- NII論文ID
- 30022678774
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- ISSN
- 15244563
- 0194911X
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