Effects of Endurance Training on Blood Pressure, Blood Pressure–Regulating Mechanisms, and Cardiovascular Risk Factors

DOI Web Site 被引用文献16件
  • Véronique A. Cornelissen
    From the Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven, Belgium.
  • Robert H. Fagard
    From the Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven, Belgium.

抄録

<jats:p> Previous meta-analyses of randomized controlled trials on the effects of chronic dynamic aerobic endurance training on blood pressure reported on resting blood pressure only. Our aim was to perform a comprehensive meta-analysis including resting and ambulatory blood pressure, blood pressure–regulating mechanisms, and concomitant cardiovascular risk factors. Inclusion criteria of studies were: random allocation to intervention and control; endurance training as the sole intervention; inclusion of healthy sedentary normotensive or hypertensive adults; intervention duration of ≥4 weeks; availability of systolic or diastolic blood pressure; and publication in a peer-reviewed journal up to December 2003. The meta-analysis involved 72 trials, 105 study groups, and 3936 participants. After weighting for the number of trained participants and using a random-effects model, training induced significant net reductions of resting and daytime ambulatory blood pressure of, respectively, 3.0/2.4 mm Hg ( <jats:italic>P</jats:italic> <0.001) and 3.3/3.5 mm Hg ( <jats:italic>P</jats:italic> <0.01). The reduction of resting blood pressure was more pronounced in the 30 hypertensive study groups (−6.9/−4.9) than in the others (−1.9/−1.6; <jats:italic>P</jats:italic> <0.001 for all). Systemic vascular resistance decreased by 7.1% ( <jats:italic>P</jats:italic> <0.05), plasma norepinephrine by 29% ( <jats:italic>P</jats:italic> <0.001), and plasma renin activity by 20% ( <jats:italic>P</jats:italic> <0.05). Body weight decreased by 1.2 kg ( <jats:italic>P</jats:italic> <0.001), waist circumference by 2.8 cm ( <jats:italic>P</jats:italic> <0.001), percent body fat by 1.4% ( <jats:italic>P</jats:italic> <0.001), and the homeostasis model assessment index of insulin resistance by 0.31 U ( <jats:italic>P</jats:italic> <0.01); HDL cholesterol increased by 0.032 mmol/L <jats:sup>−1</jats:sup> ( <jats:italic>P</jats:italic> <0.05). In conclusion, aerobic endurance training decreases blood pressure through a reduction of vascular resistance, in which the sympathetic nervous system and the renin-angiotensin system appear to be involved, and favorably affects concomitant cardiovascular risk factors. </jats:p>

収録刊行物

  • Hypertension

    Hypertension 46 (4), 667-675, 2005-10

    Ovid Technologies (Wolters Kluwer Health)

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