Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial

DOI Web Site 被引用文献30件
  • Martin J. van den Bent
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Antoine F. Carpentier
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Alba A. Brandes
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Marc Sanson
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Martin J.B. Taphoorn
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Hans J.J.A. Bernsen
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Marc Frenay
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Cees C. Tijssen
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Wolfgang Grisold
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Laslo Sipos
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Hanny Haaxma-Reiche
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Johannes M. Kros
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Mathilde C.M. van Kouwenhoven
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Charles J. Vecht
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Anouk Allgeier
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Denis Lacombe
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...
  • Thierry Gorlia
    From the Departments of Neurology and Pathology, Daniel den Hoed Cancer Center/Erasmus University Hospital, Rotterdam; Department of Neurology, Medical Center Haaglanden/Westeinde Ziekenhuis, the Hague; Canisius Wilhemina Ziekenhuis, Nijmegen; Department of Neurology, Elisabeth Gasthuis, Tilburg; Department of Neurology, Academisch Ziekenhuis Groningen, the Netherlands; Department of Neurology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris; Department of Neurology, Centre Antoine Lacassagne,...

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<jats:sec><jats:title>Purpose</jats:title><jats:p> Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a multicenter randomized controlled trial, whether adjuvant procarbazine, lomustine, and vincristine (PCV) chemotherapy improves overall survival (OS) in newly diagnosed patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> The primary end point of the study was OS; secondary end points were progression-free survival (PFS) and toxicity. Patients were randomly assigned to either 59.4 Gy of radiotherapy (RT) in 33 fractions only or to the same RT followed by six cycles of standard PCV chemotherapy (RT/PCV). 1p and 19q deletions were assessed with fluorescent in situ hybridization. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 368 patients were included. The median follow-up time was 60 months, and 59% of patients have died. In the RT arm, 82% of patients with tumor progression received chemotherapy. In 38% of patients in the RT/PCV arm, adjuvant PCV was discontinued for toxicity. OS time after RT/PCV was 40.3 months compared with 30.6 months after RT only (P = .23). RT/PCV increased PFS time compared with RT only (23 v 13.2 months, respectively; P = .0018). Twenty-five percent of patients were diagnosed with combined 1p/19q loss; 74% of this subgroup was still alive after 60 months. RT/PCV did not improve survival in the subgroup of patients with 1p/19q loss. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Adjuvant PCV chemotherapy does not prolong OS but does increase PFS in anaplastic oligodendroglioma. Combined loss of 1p/19q identifies a favorable subgroup of oligodendroglial tumors. No genetic subgroup could be identified that benefited with respect to OS from adjuvant PCV. </jats:p></jats:sec>

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