Pregnancy Among Patients With Chronic Myeloid Leukemia Treated With Imatinib

DOI Web Site 被引用文献4件
  • Patricia Ault
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Hagop Kantarjian
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Susan O'Brien
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Stefan Faderl
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Miloslav Beran
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Mary Beth Rios
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Charles Koller
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Francis Giles
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Michael Keating
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Moshe Talpaz
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • Jorge Cortes
    From the Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

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<jats:sec><jats:title>Purpose</jats:title><jats:p> Imatinib has potential teratogenicity in animals, but the effect of exposure to imatinib during conception and pregnancy in humans is not known. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> The records of all patients with chronic myeloid leukemia (CML) treated with imatinib were reviewed. We report the experience on 19 pregnancies involving 18 patients (10 females and eight males) who conceived while receiving imatinib for the treatment of CML. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> All female patients discontinued therapy immediately on recognition of pregnancy. Three pregnancies (involving two female patients and one male patient) ended in spontaneous abortion, and one patient had an elective abortion. All other pregnancies were uneventful. Two of the 16 babies had minor abnormalities at or shortly after birth (hypospadias in one baby and rotation of small intestine in one baby) that were surgically repaired. All babies have continued normal growth and development. Among female patients who interrupted therapy, five of nine in complete hematologic remission (CHR) at the time of treatment interruption eventually lost CHR, and six experienced an increase in Philadelphia chromosome–positive metaphases. At a median of 18 months after resuming therapy with imatinib, eight patients had a cytogenetic response (complete in three patients). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Although there is no evidence that a brief exposure to imatinib during conception and pregnancy adversely affects the developing fetus, most patients lose their response after treatment interruption. Patients receiving imatinib should be advised to practice adequate contraception. </jats:p></jats:sec>

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