ErbB-3 Predicts Survival in Ovarian Cancer

DOI Web Site 被引用文献5件
  • Berno Tanner
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Dirk Hasenclever
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Katja Stern
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Wiebke Schormann
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Martin Bezler
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Matthias Hermes
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Marc Brulport
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Alexander Bauer
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Ilka B. Schiffer
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Susanne Gebhard
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Markus Schmidt
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Eric Steiner
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Jalid Sehouli
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Jeanett Edelmann
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Jürgen Läuter
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Rüdiger Lessig
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • K. Krishnamurthi
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Axel Ullrich
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...
  • Jan Georg Hengstler
    From the Department of Gynecology and Obstetrics, University of Mainz, Mainz; Institute of Medical Informatics, Statistics and Epidemiology, Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm-Institute of Pharmacology and Toxicology, Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, Leipzig; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried; Department of Obstetrics and Gynecology, Charite, Berlin; Institute für Biometry and...

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<jats:sec><jats:title>Background</jats:title><jats:p> HER3 (erbB-3) is a member of the epidermal growth factor receptor (EGFR) family. After dimerization with other members of the EGFR family several signal transduction cascades can be activated, including phosphoinosite 3′-kinase (PI3-K)/Akt and extracellular signal-regulated kinase (ERK1/2). Here, we studied a possible association between HER3 expression and prognosis in patients with ovarian cancer. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Tumor tissue of 116 consecutive patients diagnosed with primary epithelial ovarian cancer between 1986 and 1995 was analyzed immunohistochemically for HER3 expression. A possible influence of HER3 expression on survival was studied by multivariate Cox regression adjusting for established clinical prognostic factors. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A positive HER3 expression was observed in 53.4% of the patients. HER3 expression was associated with decreased survival in proportional hazard modeling, including the International Federation of Gynecology and Obstetrics (FIGO) stage, histologic grade and type, residual disease, and age. After likelihood ratio forward as well as backward selection, only HER3 expression (hazard ratio, 1.71; 95% CI, 1.10 to 2.67; P = .018), FIGO stage (hazard ratio, 4.78; 95% CI, 1.89 to 12.08; P = .001), residual tumor (hazard ratio, 2.69; 95% CI, 1.40 to 5.17; P = .003), and age (hazard ratio, 2.06; 95% CI, 1.17 to 3.65; P = .013) were found to be significant. Kaplan-Meier plots demonstrated a clear influence of HER3 expression on survival time. Median survival time was 3.31 years (95% CI, 1.93 to 4.68) for patients with low HER3 expression, compared with only 1.80 years (95% CI, 0.83 to 2.78) for patients with HER3 overexpression (log-rank test P = .0034). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> HER3 may represent a new prognostic factor in primary epithelial ovarian cancer. Pending validation, exploration of therapeutic strategies to block HER3 could be warranted. </jats:p></jats:sec>

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