Identification of neural circuits underlying P300 abnormalities in schizophrenia

• Brian F. O'donnell

• Robert W. McCarley

• Geoffrey F. Potts

• Dean F. Salisbury

• Paul G. Nestor

• Yoshio Hirayasu

• Margaret A. Niznikiewicz

• John Barnard

• Zi Jen Shen

• David M. Weinstein

• Fred L. Bookstein

• Martha E. Shenton

抄録

Event‐related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp‐recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in which scalp‐recorded ERP components are correlated with underlying neuroanatomy in schizophrenia, we focused on biophysical and statistical procedures (partial least squares) to relate the auditory P300 component to anatomic measures obtained from quantitative magnetic resonance imaging. These findings are consistent with other evidence that temporal lobe structures contribute to the generation of the scalp‐recorded P300 component and that P300 amplitude asymmetry over temporal recording sites on the scalp may reflect anatomic asymmetries in the volume of the superior temporal gyrus in schizophrenia.

収録刊行物

• Psychophysiology

  Psychophysiology 36 (3), 388-398, 1999-05

  Wiley

キーワード

• Experimental and Cognitive Psychology
• Neuropsychology and Physiological Psychology
• Biological Psychiatry
• Cognitive Neuroscience
• Developmental Neuroscience
• Endocrine and Autonomic Systems
• Neurology
• General Neuroscience

詳細情報

• CRID: 1360574094168194944
• NII論文ID: 30022822896
• DOI: 10.1017/s0048577299971688
• ISSN: 14698986
• ISSN: 00485772
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1017%2FS0048577299971688
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1017/S0048577299971688
• データソース種別:
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  • CiNii Articles