Insulin Resistance Is Independently Associated With Postprandial Alterations of Triglyceride-Rich Lipoproteins in Type 2 Diabetes Mellitus

• Giovanni Annuzzi

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Claudia De Natale

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Ciro Iovine

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Lidia Patti

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Lucrezia Di Marino

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Silvana Coppola

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Stefano Del Prato

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Gabriele Riccardi

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

• Angela A. Rivellese

  From the Department of Clinical and Experimental Medicine (G.A., C.D.N., C.I., L.P., L.D.M., S.C., G.R., A.A.R.), Federico II University, Naples, and the Department of Endocrinology and Metabolism (S.D.P.), University of Pisa, Italy.

抄録

Objective— To evaluate the role of insulin resistance in development of postprandial dyslipidemia in type 2 diabetic patients in an experimental setting in which these patients were compared with nondiabetic subjects at similar glucose and insulin blood levels. Methods and Results— Eight type 2 diabetic patients in optimal blood glucose control and 7 control subjects (aged 50.0±2.6 and 48.1±1.3 years; body mass index 28.3±1.2 and 25.6±1.1 kg/m 2 ; fasting plasma triglycerides 1.12±0.13 and 0.87±0.08 mmol/L, respectively; mean±SEM; NS) consumed a mixed meal during an 8-hour hyperinsulinemic glycemic clamp. Mean blood glucose during clamp was ≈7.8 mmol/L, and plasma insulin during the preprandial steady state was ≈480 pmol/L in both groups, that differed for insulin sensitivity (M/I value lower in diabetic subjects [1.65±0.30 and 3.42±0.60; P <0.05]). Subjects with diabetes had higher postprandial levels of lipids and apolipoprotein B (apoB) in large very low-density lipoprotein (incremental area for triglycerides 1814±421 versus 549±153 μmol/L×6 hours; P <0.05; cholesterol 694±167 versus 226±41 μmol/L×6 hours; P <0.05; apoB-48 6.3±1.0 versus 2.6±0.7 mg/L×6 hours; P <0.05; apoB-100 56.5±14.9 versus 26.2±11.0 mg/L×6 hours; NS). Basal lipoprotein lipase (LPL) activity before and after meal was higher in diabetic subjects, whereas postheparin LPL activity 6 hours after the meal was similar. Conclusions— Insulin resistance is also associated with postprandial lipoprotein abnormalities in type 2 diabetes after acute correction for hyperglycemia and hyperinsulinemia.

収録刊行物

• Arteriosclerosis, Thrombosis, and Vascular Biology

  Arteriosclerosis, Thrombosis, and Vascular Biology 24 (12), 2397-2402, 2004-12

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1361137043980511104
• NII論文ID: 30023095196
• DOI: 10.1161/01.atv.0000146267.71816.30
• ISSN: 15244636
• ISSN: 10795642
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000146267.71816.30
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