Racial differences in the distribution of systemic sclerosis–related serum antinuclear antibodies

• Masataka Kuwana

• Yutaka Okano

• Junichi Kaburaki

• Takeshi Tojo

• Thomas A. Medsger

抄録

Objective. To determine racial differences in the frequencies of systemic sclerosis (SSc)–related serum antinuclear antibodies (ANA). Methods. We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc‐related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays. Results. In comparing the 3 racial groups, we found that anti–U1 RNP, anti–RNA polymerase I, II, and III, and anti–U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti–PM‐Scl antibody was found exclusively in Caucasians. Conclusion. The production of SSc‐related serum ANA is related to immunogenetic background.

収録刊行物

• Arthritis & Rheumatism

  Arthritis & Rheumatism 37 (6), 902-906, 1994-06

  Wiley

キーワード

• Pharmacology (medical)
• Immunology
• Rheumatology
• Immunology and Allergy

詳細情報

• CRID: 1364233269054289024
• NII論文ID: 30025717060
• DOI: 10.1002/art.1780370619
• ISSN: 15290131
• ISSN: 00043591
• ISSN: http://id.crossref.org/issn/00043591
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fart.1780370619
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780370619
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