Multifactorial study of prognostic factors in differentiated thyroid carcinoma and a re-evaluation of the importance of age

F Bacourt, B Asselain, J C Savoie, E D'Hubert, J P Massin, G Doucet, A Leger, H Garnier

doi:10.1002/bjs.1800730410

Multifactorial study of prognostic factors in differentiated thyroid carcinoma and a re-evaluation of the importance of age

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F Bacourt

Department of Surgery, Hôpital Amboise Paré, 9 Avenue Charles de Gaulle, 921100 Boulogne, France
B Asselain

Department of Computer Medicine of the Assistance Publique, 91 Boulevard de l'Hôpital, 75013 Paris, France
J C Savoie

Department of Nuclear Medicine, Groupe Hospitalier Pitie-Salpetriere, 91 Boulevard de l'Hôpital, 75013 Paris, France
E D'Hubert

Department of Surgery, Hôpital Amboise Paré, 9 Avenue Charles de Gaulle, 921100 Boulogne, France
J P Massin

Department of Nuclear Medicine, Groupe Hospitalier Pitie-Salpetriere, 91 Boulevard de l'Hôpital, 75013 Paris, France
G Doucet

Department of Surgery, Hôpital Amboise Paré, 9 Avenue Charles de Gaulle, 921100 Boulogne, France
A Leger

Department of Nuclear Medicine, Groupe Hospitalier Pitie-Salpetriere, 91 Boulevard de l'Hôpital, 75013 Paris, France
H Garnier

Department of Surgery, Hôpital Amboise Paré, 9 Avenue Charles de Gaulle, 921100 Boulogne, France

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<jats:title>Abstract</jats:title> <jats:p>A multivariate analysis of prognostic factors has been carried out with 375 cases of differentiated thyroid cancer (DTC) treated in the same centre by total thyroidectomy and 131I therapy. The patients have been followed for 5 to 23 years. The isolated prognostic roles of age, sex, clinical stage and histology were confirmed, but these factors were found to be strongly interrelated. Multifactorial analysis was conducted following Cox's model. It demonstrated that the prevalent role of clinical staging (nodular versus labar or massive form) is as important as the initial presence of metastases (P = 0·0001). Histological assessment of differentiation, age and sex were of lesser importance. Thus, the most significant prognostic variable is clinical stage. These data must be taken into account when formulating management protocols for DTC.</jats:p>