Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: Causes and risk factors
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- T Holm
- Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden
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- L-E Rutqvist
- Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden
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- H Johansson
- The Oncology Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden
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- B Cedermark
- Department of Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden
抄録
<jats:title>Abstract</jats:title> <jats:p>Adjuvant preoperative radiotherapy in patients with rectal cancer improves local control and possibly overall survival. However, an increased postoperative mortality rate after radiotherapy has been observed in some trials. This study was based on 1399 patients in two randomized trials of radiotherapy. It reviewed the causes of death after operation and attempted to identify risk factors for postoperative mortality in patients with rectal cancer treated with or without high-dose (5 × 5 Gy) preoperative radiotherapy. The majority of deaths were from cardio vascular disease or infection. The risk of postoperative mortality was significantly increased in patients irradiated with a two-portal technique to a relatively large volume compared with those not given radiotherapy, but not in those irradiated with a four-portal technique to a limited volume. Age, sex, tumour stage and coexistent cardiovascular disease were independent risk factors for postoperative mortality. The risk of postoperative death in patients with rectal cancer is related to the preoperative radiotherapy technique.</jats:p>
収録刊行物
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- British Journal of Surgery
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British Journal of Surgery 83 (7), 964-968, 1996-07
Oxford University Press (OUP)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1361137043500972416
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- NII論文ID
- 30026057440
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- ISSN
- 13652168
- 00071323
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- データソース種別
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