Dopamine D‐1 receptor‐mediated inhibition of micturition reflex by central dopamine from the substantia nigra

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<jats:title>Abstract</jats:title><jats:p>We examined the role of dopamine derived from the pars compacta of the substantia nigra (SN) in the micturition reflex using a‐chloralose anesthetized cats. Repetitive stimuli applied to the SN suppressed rhythmic contractions of the urinary bladder induced by continuous infusion of saline into the bladder. SN stimulation‐induced inhibition of rhythmic contractions of the urinary bladder was antagonized by intracerebroventricular administration of haloperidol, a non‐selective dopamine receptor antagonist, and SCH 23390, a dopamine D‐1 receptor antagonist. The intracerebroventricular administration of SCH 23390 alone increased the frequency of bladder contractions induced by its distension. In addition, rhythmic contractions of the urinary bladder induced by its distension were in hibited by intracerebroventricular administration of dopamine, a non‐selective dopamine receptor agonist, and SKF 38393, a dopamine D‐1 receptor agonist, but were not affected by quinpirole, a dopamine D‐2 receptor agonist. However, the bladder contraction induced by stimulation of the locus coeruleus, remained unaffected during SN stimulation. These findings suggest that central dopamine derived from the pars compacta of the SN inhibits the micturition reflex via dopamine D‐1 receptors probably in the afferent pathway form the sacral spinal cord to the locus coeruleus, although the possibility that it acts on the efferent pathways originating in areas other than locus coeruleus could not completely be excluded.</jats:p>

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