Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

• Yasumichi Mori

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Shuichi Otabe

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Christian Dina

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Kazuki Yasuda

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Céline Populaire

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Cécile Lecoeur

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Vincent Vatin

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Emmanuelle Durand

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Kazuo Hara

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Terumasa Okada

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Kazuyuki Tobe

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Philippe Boutin

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

• Takashi Kadowaki

  Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

• Philippe Froguel

  Institute of Biology-Centre National de Research Scientifique 8090, Institut Pasteur de Lille, Lille, France

抄録

The genetic background that predisposes the Japanese population to type 2 diabetes is largely unknown. Therefore, we conducted a 10-cM genome-wide scan for type 2 diabetes traits in the 359 affected individuals from 159 families, yielding 224 affected sib-pairs of Japanese origin. Nonparametric multipoint linkage analyses performed in the whole population showed one suggestive linked region on 11p13-p12 (maximum logarithm of odds score [MLS] 3.08, near Pax6) and seven potentially linked regions (MLS >1.17) at 1p36-p32, 2q34, 3q26-q28, 6p23, 7p22-p21, 15q13-q21, and 20q12-q13 (near the gene for hepatocyte nuclear factor-4α [HNF-4α]). Subset analyses according to maximal BMI and early age at diagnosis added suggestive evidence of linkage with type 2 diabetes at 7p22-p21 (MLS 3.51), 15q13-q21 (MLS 3.91), and 20q12-q13 (MLS 2.32). These results support previous indication for linkage found on chromosome 3q, 15q, and 20q in other populations and identifies two new potential loci on 7p and 11p that may confer genetic risk for type 2 diabetes in the Japanese population.

収録刊行物

• Diabetes

  Diabetes 51 (4), 1247-1255, 2002-04-01

  American Diabetes Association

キーワード

• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1363388843489721728
• NII論文ID: 30026273793
• DOI: 10.2337/diabetes.51.4.1247
• ISSN: 1939327X
• ISSN: 00121797
• ISSN: http://id.crossref.org/issn/00121797
• Web Site: https://journals.org/diabetes/diabetes/article-pdf/51/4/1247/661787/db0402001247.pdf
• Web Site: https://diabetesjournals.org/diabetes/article-pdf/51/4/1247/661787/db0402001247.pdf
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