Evidence for Early Impairment of Macular Function With Pattern ERG in Type I Diabetic Patients

DOI PDF 被引用文献1件
  • Salvatore Caputo
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Mauro A S Di Leo
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Benedetto Falsini
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Giovanni Ghirlanda
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Vittorio Porciatti
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Angelo Minella
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy
  • Aldo V Greco
    Departments of Internal Medicine and Ophthalmology, Catholic University Rome Institute of Neurophysiology, National Council of Research Pisa, Italy

抄録

<jats:p>The electroretinogram (ERG) elicited by alternating gratings at constant mean luminance (pattern ERG) is a focal response reflecting the activity of the directly stimulated retinal area. In addition, pattern ERG is related, unlike the flash ERG, to ganglion cell activity. Therefore, this technique may be used to evaluate the integrity of inner retinal layers in the macular region. In this study, the steady-state pattern ERG, in response to alternating gratings (1.7 cycles/deg spatial frequency; 9° field size) temporally modulated at 8 Hz, was recorded in 42 type I (insulin-dependent) diabetic patients with zero to four microaneurysms on fluorescein angiography and a duration of disease &lt;11 yr. No patient had concomitant ocular or systemic complications. Mean pattern-ERG amplitude was significantly reduced in patients compared with age-matched control subjects (analysis of variance, F = 25.6, P &lt; 0.0001). Significant differences were observed between control and diabetic subjects without retinopathy (Scheffe Ftest, P &lt; 0.0001), between control and retinopathic subjects (Scheffe F test, P &lt; 0.0001), and between diabetic patients without retinopathy and those with early retinopathy (Scheffé F test, P &lt; 0.02). Pattern-ERG amplitude was inversely correlated with duration of diabetes (r = 0.22, P &lt; 0.05). Our results suggest a macular dysfunction in early diabetes resulting from metabolic and/or vascular injuries in the neurosensory retina.</jats:p>

収録刊行物

  • Diabetes Care

    Diabetes Care 13 (4), 412-418, 1990-04-01

    American Diabetes Association

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ