The Finnish Diabetes Prevention Study (DPS)

DOI PDF 被引用文献17件
  • Jaana Lindström
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
  • Anne Louheranta
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
  • Marjo Mannelin
    Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
  • Merja Rastas
    Research and Development Centre, Social Insurance Institution, Turku, Finland
  • Virpi Salminen
    Institute of Nursing and Health Care, Tampere, Finland
  • Johan Eriksson
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
  • Matti Uusitupa
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
  • Jaakko Tuomilehto
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland

抄録

<jats:p>OBJECTIVE—To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short- and long-term changes in diet and exercise behavior, and 3) effect of the intervention on glucose and lipid metabolism.</jats:p> <jats:p>RESEARCH DESIGN AND METHODS—There were 522 middle-aged, overweight subjects with impaired glucose tolerance who were randomized to either a usual care control group or an intensive lifestyle intervention group. The control group received general dietary and exercise advice at baseline and had an annual physician’s examination. The subjects in the intervention group received additional individualized dietary counseling from a nutritionist. They were also offered circuit-type resistance training sessions and advised to increase overall physical activity. The intervention was the most intensive during the first year, followed by a maintenance period. The intervention goals were to reduce body weight, reduce dietary and saturated fat, and increase physical activity and dietary fiber.</jats:p> <jats:p>RESULTS—The intervention group showed significantly greater improvement in each intervention goal. After 1 and 3 years, weight reductions were 4.5 and 3.5 kg in the intervention group and 1.0 and 0.9 kg in the control group, respectively. Measures of glycemia and lipemia improved more in the intervention group.</jats:p> <jats:p>CONCLUSIONS—The intensive lifestyle intervention produced long-term beneficial changes in diet, physical activity, and clinical and biochemical parameters and reduced diabetes risk. This type of intervention is a feasible option to prevent type 2 diabetes and should be implemented in the primary health care system.</jats:p>

収録刊行物

  • Diabetes Care

    Diabetes Care 26 (12), 3230-3236, 2003-12-01

    American Diabetes Association

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