Poor Pregnancy Outcome in Women With Type 2 Diabetes

DOI PDF 被引用文献4件
  • Tine D. Clausen
    Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Elisabeth Mathiesen
    Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Pia Ekbom
    Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Ellinor Hellmuth
    Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Thomas Mandrup-Poulsen
    Steno Diabetes Center, Gentofte, Denmark
  • Peter Damm
    Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

抄録

<jats:p>OBJECTIVE— To evaluate the perinatal outcome and the frequency of maternal complications in pregnancies of women with type 2 diabetes during 1996–2001.</jats:p><jats:p>RESEARCH DESIGN AND METHODS— Medical records of 61 consecutive singleton pregnancies in women with type 2 diabetes from 1996 to 2001 were studied. Pregnancy outcome was compared with that of pregnant women with type 1 diabetes during 1996–2000, the background population, and pregnant women with type 2 diabetes during 1980–1992 from the same department.</jats:p><jats:p>RESULTS— The perinatal mortality in pregnancies complicated by type 2 diabetes (4/61, 6.6%) was increased four- and ninefold, respectively, and the rate of major congenital malformations (4/60, 6.7%) was more than doubled, although not statistically significant, compared with type 1 diabetic pregnancies and the background population. The glycemic control was similar or better in women with type 2 diabetes compared with women with type 1 diabetes. Multivariate logistic regression analysis in the pooled group of pregnancies with pregestational diabetes from 1996 to 2001 showed that high HbA1c at admission and type 2 diabetes were independently associated with a serious adverse fetal outcome (perinatal mortality and/or major congenital malformations). The perinatal mortality and the rate of major congenital malformations in type 2 diabetic pregnancies have increased during the last decade.</jats:p><jats:p>CONCLUSIONS— The perinatal outcome of pregnancies in women with type 2 diabetes during 1996–2001 is poor. It is worse than the outcome of pregnancies in women with type 1 diabetes and the background population in the same period, as well as in women with type 2 diabetes studied during 1982–1990.</jats:p>

収録刊行物

  • Diabetes Care

    Diabetes Care 28 (2), 323-328, 2005-02-01

    American Diabetes Association

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