Effect of Captopril on Glucose Concentration: Possible Role of Augmented Postprandial Forearm Blood Flow

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  • Junichi Kodama
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan
  • Shigehiro Katayama
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan
  • Kiyoshi Tanaka
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan
  • Akira Itabashi
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan
  • Shyoji Kawazu
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan
  • Jun Ishii
    Fourth Department of Medicine, Saitama Medical School Saitama, Japan

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<jats:p>The goal of this study was to evaluate the effects of captopril on plasma glucose concentration. The daily profiles of the plasma glucose levels were determined in 12 non-insulin-dependent diabetic normotensive subjects, treated with or without captopril at a dose of 25 mg 3 times/day. Forearm blood flow was also measured by strain-gauge plethysmography. Administration of captopril improved the daily profile of the plasma glucose level. Postprandial forearm blood flow was also augmented 2 h after a meal. These results suggest that angiotensin-converting enzyme inhibitors may improve glucose metabolism in diabetic subjects, possibly through enhancement of blood flow to skeletal muscle.</jats:p>

収録刊行物

  • Diabetes Care

    Diabetes Care 13 (11), 1109-1111, 1990-11-01

    American Diabetes Association

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