MPO Activity and Generation of Active O2 Species in Leukocytes From Poorly Controlled Diabetic Patients

  • Noriyuki Sato
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
  • Hiroyuki Shimizu
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
  • Kunihiko Suwa
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
  • Yohnosuke Shimomura
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
  • Isao Kobayashi
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
  • Masatomo Mori
    First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan

抄録

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Superoxide anion (O2−) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDM patients (FBG &gt;8.89 mM, HbA1 &gt;10%).</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>In diabetic subjects, both O2− production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabetic patients.</jats:p> </jats:sec>

収録刊行物

  • Diabetes Care

    Diabetes Care 15 (8), 1050-1052, 1992-08-01

    American Diabetes Association

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