MPO Activity and Generation of Active O2 Species in Leukocytes From Poorly Controlled Diabetic Patients
-
- Noriyuki Sato
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
-
- Hiroyuki Shimizu
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
-
- Kunihiko Suwa
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
-
- Yohnosuke Shimomura
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
-
- Isao Kobayashi
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
-
- Masatomo Mori
- First Department of Internal Medicine and Department of Laboratory Medicine, Gunma University School of Medicine Maebashi, Japan
抄録
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Superoxide anion (O2−) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDM patients (FBG >8.89 mM, HbA1 >10%).</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>In diabetic subjects, both O2− production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabetic patients.</jats:p> </jats:sec>
収録刊行物
-
- Diabetes Care
-
Diabetes Care 15 (8), 1050-1052, 1992-08-01
American Diabetes Association
- Tweet
詳細情報
-
- CRID
- 1362825893373420544
-
- NII論文ID
- 30026283218
-
- ISSN
- 19355548
- 01495992
-
- データソース種別
-
- Crossref
- CiNii Articles