Evaluation of nucleolar organizer region‐associated proteins in breast malignancy

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<jats:p>Nucleolar organizer regions (NORs) have been identified by means of an argyrophilic technique (Ag‐NOR) in routinely processed, formalin‐fixed paraffin sections of breast lesions. This method, which is novel in histopathology, reveals NORs as black dots in the nuclei of cells, by virtue of the argyrophilia of NOR‐associated proteins. The number of Ag‐NORs has been thought to be related to cellular activation and has recently been applied to non‐Hodgkin's lymphomas and melanocytic skin lesions. It was found in the present study that the total number of Ag‐NORs in malignant breast lesions significantly exceeded those of normal breast and benign lesions. The number of clumps of Ag‐NORs, however, were not useful discriminators. Neither numbers of total Ag‐NORs nor of clumps of Ag‐NORs correlate with mitotic counts and it may be that their numbers relate to ploidy. It is suggested that the Ag‐NOR technique will find increasing application as an adjunct to diagnostic histopathology.</jats:p>

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