The Effect of Leukotriene D<sub>4</sub> on the Patency of Nasal Passage in the Guinea Pig
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- Joong Saeng Cho
- Department of Otolaryngology, College of Medicine, Kyung-Hee University, Seoul, Korea
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- Chang Cha
- Department of Otolaryngology, College of Medicine, Kyung-Hee University, Seoul, Korea
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- Dong Yeup Lee
- Department of Otolaryngology, College of Medicine, Kyung-Hee University, Seoul, Korea
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- Kotaro Ukai
- Department of Otolaryngology, Mie University, Tsu, Japan
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- Yasuo Sakakura
- Department of Otolaryngology, Mie University, Tsu, Japan
抄録
<jats:p> We investigated the effect of leukotriene D<jats:sub>4</jats:sub>(LTD<jats:sub>4</jats:sub>) on the patency of the nasal passage in nonsensitized and sensitized guinea pigs (GPs). The change in nasal patency was measured by acoustic rhinomanometry (AR). The change of volume from the nostril to 2 cm into the nasal cavity showed significant reduction at 30 minutes and 6 hours after instillation of LTD<jats:sub>4</jats:sub> in nonsensitized GPs. These findings were also seen in nonsensitized and sensitized GPs with systemic administration of carboxyl cellulose. However, neither nonsensitized nor sensitized GP with systemic administration of benzopyren hemihydrate(ONO-1078) showed any changes in nasal patency. These results indicated that the LT was a potent medication to induce nasal obstruction of late reaction in GP. </jats:p>
収録刊行物
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- American Journal of Rhinology
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American Journal of Rhinology 12 (6), 421-426, 1998-11
SAGE Publications
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キーワード
詳細情報 詳細情報について
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- CRID
- 1361418519315635328
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- NII論文ID
- 30027730840
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- ISSN
- 15396290
- 10506586
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