Myoepithelial Cell Markers in Salivary Gland Neoplasms

• Cristiane Furuse

  Department of Oral Pathology, Sao Leopoldo Mandic Dental Research Institute, Campinas

• Suzana O. Machado de Sousa

• Fabio Daumas Nunes

• Marina Helena Cury Gallottini de Magalhaes

  Department of Oral Pathology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.

• Vera Cavalcanti de Arauijo

  Department of Oral Pathology, Sao Leopoldo Mandic Dental Research Institute, Campinas; Disciplina de Patologia Bucal, Faculdade de Odontologia USP, Av. Prof. Lineu Prestes, 2227, 05508-900, Sao Paulo-SP, Brazil.

抄録

We compared the immunoexpression of 5 myoepithelial cell (MEC) markers (asmooth-muscle actin, calponin, h-caldesmon, vimentin, and S-100-protein) using 16 pleomorphic adenomas (PA), 15 adenoid cystic carcinomas (ACC), and 3 epithelialmyoepithelial carcinomas (EMC) of salivary glands. The cx-smooth-muscle actin was useful for identification of MECs, especially in cribriform and tubular ACC, followed by EMC. Calponin was similar to ct-smooth-muscle actin, except for polygonal and plasmacytoid cells of PA and for solid ACC, which showed a-smooth-muscle actin negative and calponin positive. H-caldesmon was negative. Vimentin immunostained all MEC types, and was negative in luminal cells. S-100 protein was expressed both in the nuclei and cytoplasm of MECs and luminal cells, especially in PA. The best way to identify MEC is using a-smooth-muscle actin or calponin, plus vimentin, since in tumors MECs are hardly ever fully differentiated.

収録刊行物

• International Journal of Surgical Pathology

  International Journal of Surgical Pathology 13 (1), 57-65, 2005-01

  SAGE Publications

キーワード

• Pathology and Forensic Medicine
• Surgery
• Anatomy

詳細情報

• CRID: 1362825894663874432
• NII論文ID: 30027824502
• DOI: 10.1177/106689690501300108
• ISSN: 19402465
• ISSN: 10668969
• Web Site: http://journals.sagepub.com/doi/pdf/10.1177/106689690501300108
• データソース種別:
  • Crossref
  • CiNii Articles