Cooperative Clinical Trial of Photodynamic Therapy for Early Gastric Cancer With Photofrin Injection<sup>®</sup> and YAG-OPO Laser
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- Seishiro Mimura
- Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537, Japan
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- Hiroyuki Narahara
- Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537, Japan
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- Toshio Hirashima
- Department of Gastroenterology, Chiba Nishi General Hospital, Japan
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- Hisayuki Fukutomi
- Department of lnternal Medicine, University of Tsukuba, Japan
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- Akira Nakahara
- Department of lnternal Medicine, University of Tsukuba, Japan
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- Hiromasa Kashimura
- Department of lnternal Medicine, University of Tsukuba, Japan
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- Hirofumi Matsui
- Department of lnternal Medicine, University of Tsukuba, Japan
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- Hiroshi Tanimura
- Second Department of Surgery, Wakayama Medical School, Japan
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- Yugo Nagai
- Second Department of Surgery, Wakayama Medical School, Japan
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- Shigeru Suzuki
- Department of Gastrointestinal Endoscopy, Tokyo Women's Medical College, Japan
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- Yoko Murata
- Department of Gastrointestinal Endoscopy, Tokyo Women's Medical College, Japan
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- Kazunari Yoshida
- Department of Gastrointestinal Endoscopy, Tokyo Women's Medical College, Japan
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- Kaichi Isono
- Second Department of Surgery, Chiba University, Japan
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- Teruo Kozu
- Department of Endoscopic Diagnostics and Therapeutics, Chiba University, Japan
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- Hiroko Ide
- Department of Gastroenterology, Tokyo Women's Medical College, Japan
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- Harubumi Kato
- Margins Department of Surgery, Tokyo Medical College, Japan
抄録
<jats:p>Background and Objective: Photodynamic therapy (PDT) treats malignant tumors using photosensitizers and light. We employed a new pulse laser as the excitation light source for PDT, i.e. an optical parametric oscillator (OPO) system pumped by a Q-switched Nd:YAG laser, because it provides extremely high peak power.</jats:p><jats:p>Study Design/Materials and Methods: The effects of PDT using the photosensitizer Photofrin<jats:sup>®</jats:sup> and the new laser were evaluated in 12 patients with early gastric cancer.</jats:p><jats:p>Results: Complete responses (CR) were obtained in 75% of 12 assessable patients, CR was observed in all cases with mucosal carcinoma (response rate 100%).</jats:p><jats:p>Regarding toxicity, mild photosensitivity was seen in one case and it lasted several weeks. The other major side effect was decrease of total protein, which was observed in six patients (40%), lasting several months. There were no serious abnormalities in symptoms or laboratory tests.</jats:p><jats:p>Conclusion: We conclude that the YAG-OPO laser is suitable as an excitation light source for PDT.</jats:p>
収録刊行物
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- Diagnostic and Therapeutic Endoscopy
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Diagnostic and Therapeutic Endoscopy 4 (4), 165-171, 1998-01-01
Hindawi Limited
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詳細情報 詳細情報について
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- CRID
- 1363951796134968320
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- NII論文ID
- 30029363875
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- ISSN
- 10703608
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- データソース種別
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