Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

• Noritoshi Nagaya

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Masaaki Uematsu

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Masayasu Kojima

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Yoshihiko Ikeda

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Fumiki Yoshihara

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Wataru Shimizu

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Hiroshi Hosoda

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Yuki Hirota

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Hideyuki Ishida

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Hidezo Mori

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

• Kenji Kangawa

  From the Department of Internal Medicine, National Cardiovascular Center (N.N., W.S.), the Department of Internal Medicine, Osaka Seamen’s Insurance Hospital (M.U.), the Department of Biochemistry, National Cardiovascular Center Research Institute (M.K., F.Y., H.H., K.K.), the Department of Pathology, National Cardiovascular Center (Y.I.), and the Department of Cardiac Physiology, National Cardiovascular Center Research Institute (H.M.), Osaka, and the Department of Physiology and Research Center...

抄録

Background — Ghrelin is a novel growth hormone (GH)–releasing peptide that may also induce vasodilation and stimulate feeding through GH-independent mechanisms. We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF). Methods and Results — Ligation of the left coronary artery or sham operation was performed; 4 weeks after surgery, rat ghrelin (100 μg/kg SC BID) or saline was administered for 3 weeks. Echocardiography and cardiac catheterization were performed. Serum GH and insulin-like growth factor-1 were significantly higher in both CHF and sham rats treated with ghrelin than in those given placebo ( P <0.05 for both). CHF rats given placebo showed an impaired increase in body weight compared with sham rats given placebo ( P <0.05). CHF rats treated with ghrelin, however, showed a significantly greater increase in body weight than those given placebo (+10% versus +3%, P <0.05). They showed significantly higher cardiac output (315±49 versus 266±31 mL · min −1 · kg −1 , P <0.05) and LV dP/dt max (5738±908 versus 4363±973 mm Hg/s, P <0.05) than CHF rats given placebo. Ghrelin increased diastolic thickness of the noninfarcted posterior wall, inhibited LV enlargement, and increased LV fractional shortening in CHF rats (from 15±3% to 19±3%, P <0.05). Conclusions — Chronic subcutaneous administration of ghrelin improved LV dysfunction and attenuated the development of LV remodeling and cardiac cachexia in rats with CHF.

収録刊行物

• Circulation

  Circulation 104 (12), 1430-1435, 2001-09-18

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1362262944714990464
• NII論文ID: 30029738423
• DOI: 10.1161/hc3601.095575
• ISSN: 15244539
• ISSN: 00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/hc3601.095575
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