Accuracy of Measurement of Acoustic Rhinometry Applied to Small Experimental Animals

DOI Web Site 被引用文献2件
  • Toshihiko Kaise
    Department of Otorhinolaryngology, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan
  • Kotaro Ukai
    Department of Otorhinolaryngology, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan
  • Ole F. Pedersen
    Institute of Environmental and Occupational Medicine, University of Aarhus, Aarhus, Denmark
  • Yasuo Sakakura
    Department of Otorhinolaryngology, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan

抄録

<jats:p> Nasal obstruction is one of the major symptoms of allergic rhinitis. In the study of the mechanism of nasal obstruction, experiments on animal are useful. In adult humans, acoustic rhinometry has been used to evaluate nasal obstruction by determining nasal cavity dimensions in terms of cross-sectional areas as a function of the distance from the nostril. We modified the equipment used on humans to assess dimensions of nasal airway geometry of small experimental animals. The purpose of this study was to investigate the accuracy of measurement of the modified acoustic rhinometry applied to small experimental animals using nasal cavity models and guinea pigs. Measurement of the nasal cavity models (made of cylindrical silicone tubes) showed that the acoustic rhinometry estimated 85.5% of actual area and 79.0% of actual volume. In guinea pigs, nasal cavity volume determined by the acoustic rhinometry was 73.7 ± 20.0% of actual volume. The actual volume was estimated by impression material instilled into the nasal cavity of the animals (IM volume), and volume determined by acoustic rhinometry significantly correlated with IM volume. Furthermore, there was a significant negative correlation between the volume and nasal airway resistance in guinea pigs. Measurement of the nasal airway resistance is the method frequently used in the evaluation of the nasal obstruction in guinea pigs. These results suggest that acoustic rhinometry is useful in evaluating nasal obstruction in small experimental animals. </jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ