Association Between Infection With <i>Helicobacter pylori</i> and <i>Chlamydia pneumoniae</i> and Risk of Ischemic Stroke Subtypes

• Peter U. Heuschmann

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Daniel Neureiter

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Markus Gesslein

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Benjamin Craiovan

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Matthias Maass

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Gerhard Faller

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Georg Beck

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Bernhard Neundoerfer

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

• Peter L. Kolominsky-Rabas

  From the Unit for Stroke Research and Public Health Medicine, Department of Neurology (P.U.H., M.G., B.C., B.N., P.L.K-R.), Department of Pathology (D.N., G.F.), and Institute of Neurobiochemistry, Department of Psychiatry (G.B.), University of Erlangen; and Institute for Medical Microbiology and Hygiene, Medical University of Luebeck (M.M.) (Germany).

書誌事項

タイトル別名

• Results From a Population-Based Case-Control Study

抄録

Background and Purpose — Helicobacter pylori and Chlamydia pneumoniae have been associated epidemiologically and pathogenetically with coronary atherosclerosis. However, population-based data on chronic infection and stroke are lacking. Therefore, we investigated the association of both bacterial pathogens and ischemic stroke subtypes in a population-based case-control study. Methods — Patients with first ischemic stroke in the population-based Erlangen Stroke Project were collected as cases. Neighborhood controls were drawn from the study population, matched for age, sex, and place of residence. IgG antibodies to H pylori were measured by enzyme immunoassay, and IgG antibodies to C pneumoniae were measured by microimmunofluorescence technique. Conditional logistic regression was used. Analyses were stratified for etiologic stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Results — A total of 145 case and 260 control subjects were included. Chronic H pylori infection was associated with a higher risk of stroke caused by small-artery occlusion (adjusted odds ratio, 3.31; 95% CI, 1.15 to 9.56) and a lower risk of cardioembolic stroke (adjusted odds ratio, 0.21; 95% CI, 0.06 to 0.71). Overall, elevated H pylori as well as elevated C pneumoniae antibodies were not associated with ischemic stroke. Conclusions — Our population-based study does not provide evidence of any strong association between the immune response to C pneumoniae as a marker of prior infection and ischemic stroke. Further studies are required to reveal the role of chronic H pylori infection as an independent risk factor for the subgroup small-artery occlusion.

収録刊行物

• Stroke

  Stroke 32 (10), 2253-2258, 2001-10

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Advanced and Specialized Nursing
• Cardiology and Cardiovascular Medicine
• Neurology (clinical)

詳細情報

• CRID: 1361699994923175936
• NII論文ID: 30030005679
• NII書誌ID: AA0085085X
• DOI: 10.1161/hs1001.097096
• ISSN: 15244628
• ISSN: 00392499
• Web Site: https://www.ahajournals.org/doi/full/10.1161/hs1001.097096
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