Fas Ligand Expression in Glioblastoma Cell Lines and Primary Astrocytic Brain Tumors

• Catherine Gratas

• Yasuo Tohma

• Erwin G. Van Meir

• Michael Klein

• Mirna Tenan

• Nobuaki Ishii

• Osamu Tachibana

• Paul Kleihues

• Hiroko Ohgaki

抄録

Fas/APO‐1 (CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand (FasL) or Fas antibody. We previously reported that Fas expression is predominantly induced in perinecrotic glioma cells, suggesting that Fas induction is associated with apoptosis and necrosis formation, a histological hallmark of glioblastomas. In this study, we assessed the expression of FasL in 10 glioblastoma cell lines and in 14 astrocytic brain tumors (three low‐grade astrocytomas and 11 glioblastomas). Reverse transcriptase (RT)‐PCR revealed that all glioblastoma cell lines and primary astrocytic brain tumors express FasL. Immunohistochemically, FasL was predominantly expressed on the plasma membrane of glioma cells. These results suggest that FasL expression is common in human astrocytic brain tumors and may cause apoptosis of glioma cells if Fas expression is induced.

収録刊行物

• Brain Pathology

  Brain Pathology 7 (3), 863-869, 1997-07

  Wiley

キーワード

• Neurology (clinical)
• Pathology and Forensic Medicine
• General Neuroscience

詳細情報

• CRID: 1361137046367148800
• NII論文ID: 30034592632
• NII書誌ID: AA10776221
• DOI: 10.1111/j.1750-3639.1997.tb00889.x
• ISSN: 17503639
• ISSN: 10156305
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1750-3639.1997.tb00889.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1750-3639.1997.tb00889.x
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