Chronic Inhibition of Nitric Oxide in Central Nervous System Does Not Cause Hypertension.

• Wada Yoshifumi

  Department of Internal Medicine III, Kurume University School of Medicine

• Matsuoka Hidehiro

  Department of Internal Medicine III, Kurume University School of Medicine

• Okuda Seiya

  Department of Internal Medicine III, Kurume University School of Medicine

• Imaizumi Tsutomu

  Department of Internal Medicine III, Kurume University School of Medicine

抄録

Acute inhibition of nitric oxide (NO) synthase in the brain causes elevation of blood pressure and sympathetic excitation under anesthetized conditions. To investigate chronic effects of NO synthase inhibition in the central nervous system on blood pressure regulation in conscious unrestrained animals, we administered N^G-monomethyl-L-arginine (L-NMMA), a potent NO synthase inhibitor, at low (22.5 μmol/kg) and high (67.5μmol/kg) doses for 1wk into the cisterna magna with an osmotic pump and measured mean arterial pressure (MAP) and heart rate (HR) by a telemetry method. The same dose of N^G-monomethyl-D-arginine (D-NMMA), an inactive isomer of L-NMMA, was administered to control rats. Chronic intracisternal administration of low-dose L-NMMA significantly decreased the brain nitrite/nitrate and NO metabolite contents as compared with D-NMMA (p<0.05). However, MAP and its variability, HR and its variability, and plsma norepinephrine levels did not differ between the two groups of rats at either low- or high-dose treatment. Thus, chronic NO synthase inhibition in the central nervous system did not affect systemic hemodynamics or plasma norepinephrine concentrations despite the inhibition of brain NO. Our results suggest that endogenous NO in the central nervous system, ats least as a whole, may not affect the systemic hemodynamics of chronic unanesthetized rats. (Hypertens Res 1998; 21: 97-101)

収録刊行物

• Hypertension Research

  Hypertension Research 21 (2), 97-101, 1998

  日本高血圧学会

キーワード

• brain
• sympathetic nervous system
• blood pressure variability
• nitrate

詳細情報

• CRID: 1390282679698102144
• NII論文ID: 130003456367
• NII論文ID: 30034931934
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.21.97
• COI: 1:CAS:528:DyaK1cXksFaht7c%3D
• ISSN: 13484214
• ISSN: 09169636
• ISSN: http://id.crossref.org/issn/09169636
• PubMed: 9661805
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可