Acute and chronic effects of thyrotropin-releasing hormone (TRH) on stabilogram in spinocerebellar degenerations.

  • YOSHIDA MOTOAKI
    Department of Neurology, Institute of Clinicical Medicine, University of Tsukuba
  • NAKANISHI TAKAO
    Department of Neurology, Institute of Clinicical Medicine, University of Tsukuba
  • KOMATSU YOSHINARI
    Department of Neurology, Institute of Clinicical Medicine, University of Tsukuba

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YOSHIDA, M., NAKANISHI, T. and KOMATSU, Y. Acute and Chronic Effects of Thyrotropin-Releasing Hormone (TRH) on Stabilogram in Spinocerebellar Degenerations. Tohoku J. exp. Med., 1986, 148 (3), 327-331 - A single blind cross over trial was conducted of thyrotropin-releasing hormone treatment in 7 patients with spinocerebellar degenerations. Patients received daily 2mg of thyrotropin releasing hormone intramuscularly during the 2 week treatment period. Acute beneficial effect on stabilogram was demonstrated, but significant therapeutic efficacy in the chronic treatment failed to be demonstrated, though a trend of effectiveness was observed.

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