Development of resistance to activated protein C during pregnancy

• A. M. CUMMING

• R. C. TAIT

• S. FILDES

• A. YOONG

• S. KEENEY

• C. R. M. HAY

Abstract

Summary. We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14‐20, 28 and 36 weeks gestation, and at 1 d post‐partum. Significant reductions in the mean APC sensitivity ratio (APC‐SR) were observed at all stages of pregnancy studied compared with the mean APC‐SR obtained for baseline measurements carried out at > 8 weeks post‐partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14‐20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.

Journal

• British Journal of Haematology

  British Journal of Haematology 90 (3), 725-727, 1995-07

  Wiley

Keywords

• Hematology

Details

• CRID: 1362262944105310080
• NII Article ID: 30035615127
• DOI: 10.1111/j.1365-2141.1995.tb05610.x
• ISSN: 13652141
• ISSN: 00071048
• ISSN: http://id.crossref.org/issn/00071048
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2141.1995.tb05610.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2141.1995.tb05610.x
• Data Source:
  • Crossref
  • CiNii Articles