Effect of Nucleotide Restriction and Supplementation on Resistance to Experimental Murine Candidiasis

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<jats:p>The influence of dietary nucleotides on susceptibility to candidiasis in mice was studied using two criteria: animal survival and recovery of viable Candida <jats:italic>albicans</jats:italic> organisms from the kidney and spleen. One‐month‐old mice were placed on one of five diets with varying nucleotide content. The results show that mice maintained on a nucleotide‐free diet (NF) exhibit a significantly decreased mean survival time and a significantly increased viable organism recovery in the spleen following intravenous injection of graded inocula of C. albicans compared to mice fed diets containing RNA or uracil as a nucleotide source. <jats:italic>(Journal of Parenteral and Enteral Nutrition</jats:italic> 12:49–52, 1988)</jats:p>

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