Association of HLA‐DR3 with human immune response to <i>Lol p</i> I and <i>Lol p</i> II allergens in allergic subjects

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<jats:p>Associations between HLA type and IgE or IgG antibody (Ab) responses to two well‐characterized, antigenetically non‐crossreactive components of <jats:italic>Lolium perenne</jats:italic> (rye grass) pollen extract, <jats:italic>Lot p</jats:italic> I (Rye I) and <jats:italic>Lolp</jats:italic> II (Rye II) were studied in two groups of skin‐test positive (ST+) Caucasoid adults. By both nonparametric and parametric statistical methods, significant associations were found between Ab responses to both <jats:italic>Lol</jats:italic> I arid <jats:italic>Lol</jats:italic> II and the possession of HLA‐DR3. In view of the well‐known associations of both DR3 and B8 (which are in linkage disequilibrium) with many autoimmune diseases, differences in anti‐<jats:italic>Lol</jats:italic> I and anti‐<jats:italic>Lol</jats:italic> II mean log[Ab] levels between B8+, DR3‐vs B8‐, DR3‐subjects and B8+, DR3+ vs B8‐, DR3+ subjects were investigated. No differences were found. Our data, along with recent RFLP and DNA sequence studies, suggest that an Ia molecule involved in immune recognition of a similar major Ia recognition site of both the <jats:italic>Lol</jats:italic> molecules may consist of a DR3α‐β, pair.</jats:p>

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