急性感染症とその化学療法におよぼす非ステロイド性消炎剤の影響についての実験的研究

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タイトル別名
  • EXPERIMENTAL STUDIES ON THE INFLUENCE OF NON-STEROIDAL ANTIINFLAMMATORY AGENTS ON CHEMOTHERAPY FOR ACUTE INFECTIOUS DISEASES
  • キュウセイ カンセンショウ ト ソノ カガク リョウホウ ニ オヨボス ヒ ス

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Influences of antiinflammatory agents on acute infections and the chemotherapy for them were studied. In these studies BCP (bucolome) and OPB (oxyphenbutazone) were used as antiinflammatory agents. The results obtained were as follows.<BR>1) As the result of decrease of urinary excretion of PCG in animals pretreated with BCP or OPB, serum levels, tissue levels and exudate levels of PCG in these animals are higher than in those with out BCP or OPB administration. Urinary excretion, serum levels, tissue levels and exudate levels of TC in animals are not influenced by pretreatment with antiinflammatory agents.<BR>2) RES function in rabbits measured by hen's erythrocytes method is hardly influenced by administration of antiinflammatory agents.<BR>3) Antibody formation against Shigella flexneri 2 a in rabbits is inhibited by administration of OPB.<BR>4) Pretreatment with antiinflammatory agents seems to aggravate pneumococcal septicemia in mice. However, the pretreatment with antiinflammatory agents sometimes seems to increase the curative effect of PCG to pneumococcal septicemia in mice.<BR>5) In rabbits and mice, the localization of subcutaneous abscess caused by Staphylococcus aureus is suppressed histologically, even when the abscess macroscopically seems to be milder by combined administration of antibiotics (PCG or TC) and antiinflammatory agents.

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