Improvement of macrolide antibiotic-producing streptomycete strains by the regeneration of protoplasts.
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- IKEDA HARUO
- John Innes Institute
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- INOUE MASAHARU
- School of Pharmaceutical Sciences, Kitasato University and The Kitasato Institute
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- OMURA SATOSHI
- School of Pharmaceutical Sciences, Kitasato University and The Kitasato Institute
書誌事項
- タイトル別名
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- Improvement of Macrolide Antibiotic Pro
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抄録
Three macrolide antibiotic-producing strains, the spiramycin producer Streptomyces ambofaciens, the tylosin producer Streptomyces fradiae, and the cirramycin producer Streptomyces cirratus easily formed protoplasts when treated with lysozyme in hypertonic medium. Each type of protoplast was regenerated to a mycelial form at a frequency of 90 to 100% in regeneration medium supplemented with a plasma expander. In the spiramycin producer S. ambofaciens and the tylosin producer S. fradiae, antibiotic productivities of the regenerated progeny were drastically changed. Some regenerated progeny from the three strains gave higher production. One from S. ambofaciens showed about twice the productivity of the original strain and one obtained after two rounds of protoplast regeneration from S. fradiae produced about three times as much as the original strain.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 36 (3), 283-288, 1983
公益財団法人 日本感染症医薬品協会
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詳細情報
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- CRID
- 1390282679128671488
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- NII論文ID
- 130003500413
- 40000017384
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaL3sXhslOnsbY%3D
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- ISSN
- 18811469
- 00218820
- http://id.crossref.org/issn/00218820
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- NDL書誌ID
- 2625518
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- PubMed
- 6833148
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可