準台形波刺激による神経興奮の伝導ブロックに関する基礎的検討

DOI 機関リポジトリ Web Site

書誌事項

タイトル別名
  • Basic Study on Blockling Nerve Conduction with Slowly-Rising Pulse Stimulation.
  • ジュン ダイケイハ シゲキ ニ ヨル シンケイ コウフン ノ デンドウ ブロッ

この論文をさがす

抄録

Functional electrical stimulation (FES) has been proposed as a technique that could reconstruct the paralized functional mobility of the patients who injured their spinal cord and so on. A new method with which nerve conduction could be blocked electrically was studied in this report in order to suppress an undesirable excitation caused by the spinal reflex in applying FES clinically. The method for blocking nerve conduction electrically seems to be useful in applying FES to the patients widely. Some methods for it have been already proposed, neither of which, however, has been applied clinically. Slowly-rising pulse stimulation was proposed in this report as a new method for it. The proposed stimulation might be used clinically because nerve conduction was expected to be blocked locally with a relevant electrical stimulus intensity. First of all, we tried to confirm the ability to block nerve conduction in Frankenhaeuser-Huxley model simulation. Next, acute animal experiments with 3 rabbits were performed in order to evaluate the effect of the stimulation practically. It was found in simulation that nerve conduction could be blocked locally with the slowly-rising pulse stimulation which had the relevant stimulus intensity. On the other hand, it was indicated in the animal experiments that the greater the rise time of the stimulus pulse was, the higher the stimulus threshold was. The tibial nerve was stimulated by a cuff electrode while the EMG signals were recorded from the medial gastrocnemius innervated by the nerve in each of the animal experiments. From analyzing the parameters used in the simulation, these results seem to be caused by the inactivated membrane of nerve fibers. The probability that nerve conduction could be blocked with the slowly-rising pulse stimulation was confirmed with the results of the simulation and the acute animal experiments is this report.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ