CARCINOGENIC EFFECT OF N-ETHYL- AND N-AMYL-N-NITROSOURETHANS ON FEMALE DONRYU RATS

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  • HIROSE Masao
    First Department of Pathology, Nagoya City University Medical School
  • MAEKAWA Akihiko
    Department of Pathology National Institute of Hygienic Sciences
  • KAMIYA Shozo
    Department of Synthetic Chemistry National Institute of Hygienic Sciences
  • ODASHIMA Shigeyoshi
    Department of Pathology National Institute of Hygienic Sciences

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  • Carcinogenic Effect of N-Ethyl- and N-Amyl-N-Nitrosourethans of Female Donryu Rats
  • Carcinogenic Effect of N Ethyl and N Am

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Abstract

Carcinogenic effect of N-ethyl-N-nitrosourethan (ENUR) and N-amyl-N-nitrosourethan (ANUR) was examined by continuous oral administration or topical application to female Donryu rats. Oral administration of 100ppm solution of ENUR induced 100% of tumors in the forestomach, 46%, 80%, 71%, and 51% in the oral cavity and pharynx, esophagus, duodenum, and liver, respectively. On the other hand, the incidence of forestomach tumors was 78%, that of oral cavity and pharynx, and esophagus was 93% and 98%, respectively, in rats given 400ppm suspension of ANUR.<br>In addition, topical application of ENUR induced tumors of the skin as well as tumors of the forestomach and liver.

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