3'-Methyl-4-Dimethylaminoazobenzeneによるラット肝発癌過程におけるγ-Glutamyl Transpeptidase活性の生化学的, 組織化学的研究

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タイトル別名
  • Biochemical and Histochemical Study of γ-Glutamyl Transpeptidase during Hepatocarcinogenesis of Rat Fed 3'-Methyl-4-Dimethylaminoazobenzene
  • 3′-Methyl-4-Dimethylaminoazobenzeneによるラット肝発癌過程におけるγ-Glutamyl Transpeptidase活性の生化学的,組織化学的研究
  • 3 Methyl 4 Dimethylaminoazobenzene ニヨル

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γ-Glutamyl transpeptidase （γ-GTP） activity in rat livers during 3'-methyl-4-dimethylaminoazobenzene （3'-Me-DAB） carcinogenesis was studied biochemically in comparison with normal adult,neonatal, and fetal livers. Biochemically, the γ-GTP activity increased in livers after 3'-Me-DAB feeding, and a small peak of activity was observed around the 5th week. Intense reaction products for γ-GTP staining were observed on the apical surface of "oval cells" and in the bile canaliculi of renewed small hepatocytes. After 7 weeks the γ-GTP activity accelerated increasingly with the lapse of time. Atthe 16th week, the activity was about 30 times higher than that of normal adult livers. Histochemical localization for y-GTP activity was mainly observed in the bile canaliculi of hepatocytes which constitute the hyperplastic foci and nodules. Intense y-GTP activity was observed throughout the entire cell membrane of hepatocytes in late nodules and hepatomas with trabecular pattern and occasionally in the cytoplasm of hepatoma cells. The significance of the staining pattern for γ-GTP in the cells of hyperplastic nodules and hepatomas is discussed and is compared with that in developing livers.

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