人,ネフローゼ症候群における胃癌関連抗原の役割

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タイトル別名
  • A POSSIBLE ROLE OF GASTRIC CANCER ANTIGENANTIBODY COMPLEXES IN NEPHROTIC SYNDROME
  • ヒト ネフローゼ ショウコウグン ニ オケル イガン カンレン コウゲン ノ

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Two patients of nephrotic syndrome with gastric carcinoma we presented. Examination of routine renal biopsy revealed the characteristic light, immunofluorescent and electronn microscopic features of membranous nephropathy. Subepithelial electron-dense deposits were corresponded to immunofluorescent deposits containing IgG and beta-l-c in the two cases. When tested by immunodiffusion, there was a line between the glomerular eluate obtained from the glomeruli of the patient's and carcinoembryonic antigen (CEA), prepared. And this eluate reacted specifically the surface of patients' tumor cells. The reactivity of the eluate was aboiisned by absorption of an extract of patient, s tumor tissue and CEA prepared. In addition, CEA was also demonstrated in the patients' urines. These events suggest that an immune mechanism related the gastric carcinoma is responsible for the glomerular lesion. Probably it is carcinoembryonic antigen-antibody complexes to have induced the nephropathy.

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