急性血清病じん炎における血小板の役割について

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  • The Role of Platelets on Acute Serum Sickness Nephritis of Rabbits
  • キュウセイ ケッセイビョウ ジンエン ニ オケル ケッショウバン ノ ヤクワリ

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In order to clarify the role of platelets on immune complexes nephritis, we investigated that the behavior of platelets, that is, the immune release of chemical mediators, platelet-surface immunoglobmlins and platelet functions during acute serum sickness nephritis. The following results were obtained. The immune release of vasoactive amines, especially serotonin (5-HT) from platelets were existed at the time of immune elimination and before the appearances of proteinuria. Immunoglobulins were bound to the surface of platelets when the 5-HT release from platelets was occured. And the ability of platelet aggregation induced by addition of ADP was decreased at the same time. Nevertheless the survival rate of platelets was within normal range. The deposition of immune complexes to the kidney tissues was increased by the addition of chemical mediators from platelets. Further by the treatment of anti-platelet drug, dipyridamole undergoing acute serum sickness nephritis, the release of 5-HT from platelets, proteinuria and the deposition of immune compleyes were inhibited. We concluded that in acute serum sickness nephritis of rabbits, the immune release of vasoactive amines from platelets by means of binding to C3 receptors of rabbit platelets may play important roles on the deposition of immune complexes and pathogenesis of glomerulonephritis.

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