書誌事項
- タイトル別名
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- Tissue distribution of red blood cells treated with X-ray contrast media in rats.
- Xセン ゾウエイザイ ショリ セッケッキュウ ノ ラット タイナイ ドウタイ
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抄録
Tissue distribution of red blood cells (RBC) that were treated with X-ray contrast media was investigated in rats. The contrast medium mixed with an equivolume of 51Crlabelled RBC was administered to the internal carotid artery in a dose of 200μl/rat; and the radioactivity in the brain, lung and spleen were determined. The contrast medium mixed with an equivolume of blood was administered to the right atrium in a dose of 4 ml/kg, and the hemoglobin content in the lung and changes in pulmonary and circulatory functions were determined. In the ionic contrast medium (meglumine diatrizoate) -treated group, the radioactivity in the brain remained 30 to 50 times higher compared with the nonionic contrast medium (iopamidol) -and saline-treated group until 15 min after infusion. The radioactivity in the spleen increased and the radioactivity and hemoglobin content in the lung decreased time-dependently in the diatrizoate-treated group, whereas iopamidoland saline-treated groups exhibited constantly low values during the experimental period. Changes in the airway pressure, pulmonary arterial pressure, systemic blood pressure and heart rate were similar after intra-atrial administration of diatrizoate mixed with blood and diatrizoate mixed with saline. These results suggest that the ionic contrast medium affects the RBC and causes a microcirculatory disturbance in the brain.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 95 (3), 105-112, 1990
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204272485504
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- NII論文ID
- 40003049923
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXhvFCmtrc%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3659430
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- PubMed
- 2354831
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可