真性多血症の鉄代謝

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書誌事項

タイトル別名
  • Ferrokinetics in Polycythemia Vera
  • 真性多血症の鉄代謝--とくにWhole Body Linear Scanningを中心として
  • シンセイ タケツショウ ノ テツ タイシャ トクニ Whole Body Li
  • —とくにWhole Body Linear Scanningを中心として—
  • —With Special Reference to Whole Body Linear Scanning—

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抄録

The distribution patterns of the erythropoietic marrows in 17 patients with polycythemia vera were evaluated with a Ring-type Whole Body Linear Scanning using 59Fe. Ferrokinetics indices calculated by Huff's method were as follows: PID T1/2 42±24 min. (Mean±S.D.), RCU 86±17%, PIT 1.00±0.58 mg/kg/day, EIT 0.91±0.61 mg/kg/day. RCU and EIT in polycythemia vera cases with myelofibrotic change were lower than those in polychytemia vera cases without myelofibrotic change. After the injection of 59Fe, the longitudihal as well as transverse linear scanning were performed at 6 hours, 24 hours, 5th day and 10th day period. The distribution patterns of 59Fe at 24 hours, which reflect the erythropoietic marrow distribution, were devided into 3 patterns, that is, normal, marrow expansion and extramedullary erythropoiesis. Among 20 cases, 5 had normal, 7 had marrow expansion and 13 had extramedullary erythropoiesis. The frequency of extramedullary erythropoiesis was significantly high in patients with splenomegaly. The accumulation of 59Fe at the 10th day in the spleen reflecting the hemolysis and the pooling of the red cell was found in 19 among 20 cases with polycythemia vera. The whole body linear scanning is useful for the diagnosis, treatment and studies of pathophysiology of polycythemia vera.

収録刊行物

  • 臨床血液

    臨床血液 17 (5), 520-526, 1976

    一般社団法人 日本血液学会

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