Extramedullary IgG (λ) Plasmacytoma with Polyneuritis and Pigmentation

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Other Title
  • 多発性神経炎，皮膚症状を伴ったIgG (λ)型髄外性形質細胞腫の一例
  • 多発性神経炎,皮膚症状を伴ったIgG(λ)型髄外性形質細胞腫の1例
  • タハツセイ シンケイエン ヒフ ショウジョウ オ トモナッタ IgG ラムダ

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Abstract

In 1968 Fukase et al reported a case of solitary myeloma with polyneuritis and endocrine abnormalities. In 1973 Takatsuki et al proposed the hypothesis that plasma cell dyscrasia accompanying polyneuritis, pigmentation and endocrine abnormalities such as gynecomastia may belong to a syndrome. We, recently, experienced a case of extramedullary IgG plasmacytoma with polyneuritis, pigmentation and autonomic neuropathies including paralytic ileus, constipation and hypotension. Immunohistochemical study for peptide hormones in the materials of biopsy revealed that this tumor did not contain ACTH, β-MSH, substance P β-endorphin and neurotensin like immunoreactivities. This finding, therefore, suggested that pigmentation, polyneuritis and hypotension of this case did not result from effects of peptide hormones mentioned above. Thus, it seems likely that symptoms of this case may be due to effects of unknown substances.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 23 (6), 870-874, 1982

    The Japanese Society of Hematology

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