メチマゾールにより顆粒球減少症を呈し，患者リンパ球が骨髄細胞由来の顆粒球系コロニー形成を抑制した甲状腺機能亢進症の一例

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タイトル別名
  • A Case of Hyperthyroidism Associated with Granulocytopenia Induced by Methimazole, Whose Peripheral Blood Lymphocytes Suppressed Granuloid Colony Formation from Patient's Bone Marrow
  • メチマゾールにより顆粒球減少症を呈し,患者リンパ球が骨髄細胞由来の顆粒球系コロニー形成を抑制した甲状腺機能亢進症の1例
  • メチマゾール ニ ヨリ カリュウキュウ ゲンショウショウ オ テイシ カンジャ

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A 33 years old male was admitted to our hospital because of struma, palpitation and finger tremor. The diagnosis of hyperthyroidism was made by physical and laboratory examinations, then antithyroid drug (methimazole) therapy was begun. Twelve days after the start of the therapy, he showed high fever and leukocytopenia, especially neutropenia (350/cmm). Few days after withdrowing methimazole and begining of antibiotics, clinical and hematological findings were recovered normally.<br>The effect of methimazole, serum and peripheral blood lymphocytes of patient on colony formation from CFU-C was examined in the semisolid agar culture system. There was substantial decrease in CFU-C colony numbers only when both methimazole and peripheral blood lymphocytes of patient were added in the culture. On the otherhand, neither methimazole only nor combination of methimazole and patient's serum suppressed the colony formation.<br>It was suggested that peripheral blood lymphocytes were playing an important role in this suppression of CFU-C colony formation, and furthermore in the cause of agranulocytosis in vivo through the immunological mechanism.

収録刊行物

  • 臨床血液

    臨床血液 23 (8), 1211-1216, 1982

    一般社団法人 日本血液学会

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