Intercalation Compounds of Layered Titanium Phosphate for Drug Delivery Use

• TAJIMA Tomoko

  <I>Showa Pharmaceutical University</I>

• SUZUKI Noriko

  <I>Showa Pharmaceutical University</I>

• WATANABE Yoshiteru

  <I>Showa Pharmaceutical University</I>

• KANZAKI Yasushi

  <I>Showa Pharmaceutical University</I>

抄録

Layered inorganic material, γ-titanium phosphate (γ-TiP), was applied as a host material for drug delivery use. Hygroscopic diclofenac sodium (DFS) was selected as a model drug to improve its anti-humidity and anti-oxidation. The intercalation was carried out in ethanol solution of DFS. Propylamine was used as the third compound to expand interlayer gallery and/or exfoliate lamellae. The amount of intercalated DFS was almost independent on the concentration of propylamine added. The drug release characteristics was also investigated. The release rate of DFS from the intercalation compound was slower than DFS powder and almost all DFS intercalated was released within 120 min.

収録刊行物

• 日本イオン交換学会誌

  日本イオン交換学会誌 14 (Supplement), 177-180, 2003

  日本イオン交換学会

詳細情報

• CRID: 1390282679411616256
• NII論文ID: 40005923335
• NII論文ID: 130004162336
• NII書誌ID: AN10185781
• DOI: 10.5182/jaie.14.supplement_177
• ISSN: 18843360
• ISSN: 0915860X
• ISSN: http://id.crossref.org/issn/01662740
• NDL書誌ID: 6683464
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6683464
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可